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UCHL1 deubiquitinates SMAD2. 2 / 3

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"UCHL1 promoted TGFβ-SMAD signaling by deubiquitinating the TGFβ type I receptor and SMAD2, resulting in enhanced metastasis [94]."

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"In a separate study using a DUB activity profiling approach Liu et al. identified UCHL1 as a particularly active DUB in TNBC, proposing that UCHL1 also promotes TGF-β-induced TNBC metastasises by deubiquitinating and stabilising TGFβR1 and SMAD2 [54]."

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UCHL1 deubiquitinates SMAD2. 2 / 3

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