IndraLab

Statements

USP35 inhibits Interferon. 3 / 3
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"Our findings further underscore the role of USP35 in negatively regulating the MAVS-TBK1-IRF3 signaling pathway, and the knockdown of USP35 enhances type I interferon and inflammation-related factor expression in response to cytoplasmic RNA virus or RNA analog.MAVS is an essential adapter protein in the RLR pathway and plays a key role in the production of type I IFN [29]."
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"A recent study suggests that USP35 interacts with STING to regulate STING activity and suppresses the antiviral type-I interferon response [17]."
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"Lastly, USP35 suppressed anti-tumor immunity of type I interferon through the STING/TBK1/IRF3 pathway and as a result, chemoresistance was induced [113,159,160,161]."
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