IndraLab

Statements

Emodin inhibits MYD88. 4 / 4
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"The present data indicated that emodin inhibited TLR4 signaling via both MyD88-dependent and -independent pathways, and thus it was hypothesized that the antitumor activity of emodin depends on the inhibition of NF-κB via downregulation of the TLR4 signaling pathway.The present study revealed downregulation of proliferative factors, including c-Myc, cyclin D1 and PCNA, as well downregulation of anti-apoptotic Bcl-2, and upregulation of the pro-apoptotic factor Bax in PTC cell lines exposed to emodin."
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"Taken together, emodin may inhibit the activity of MyD88 and block transmission of the TLR signalling pathway to limit the proliferation of immune cells, suppress inflammatory responses induced by PI3K/Akt/NF-κB in microglia, and improve the clinical symptoms of EAE/MS."
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"Emodin inhibits microglia activation by inhibiting MyD88 activation."
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"Therefore, we determined the expression levels of these related proteins, and the results indicated that emodin could significantly downregulate the HTRA1, IL-33, MyD88, TRAF-6, and NF-kappaB protein levels, but upregulate the TGF-beta1 protein level, and decrease the TNF-alpha, IL-1beta, and IL-6 mRNA levels."
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