IndraLab

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"That is, while we know that a variety of nanoparticles cause inflammasome activation, little if any work has explored the idea that some useful property inherent to a particular type of nanoparticle could actually be exploited to inhibit inflammasome activation.Here we found that nickel-cobalt alloy nanocrystals (NiCo NCs) efficiently inhibit the activation of NLRP3 inflammasomes by multiple agonists."
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"A previous study confirmed that Al impairs cognitive function in mice by activating the hippocampal NLRP3 inflammasome and pyroptosis [ 18 ]."
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"Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes."
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"Alum und LLOMe, on the other hand, degraded inflammatory proteins (including caspase-1), inhibited NALP3 signaling and led to necrotic death [XREF_BIBR]."
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"A possible role for the NACHT, LRR and PYD domains—containing protein-3 (NLRP3) inflammasome was also proposed [44–46] , as it had been reported that alum-induced immune responses were abrogated in NL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"(2) Model of Lysosomal DisruptionCrystalline or particulate NLRP3 agonists such as MSU, silica and alum are engulfed, and their physical characteristics lead to lysosomal rupture, resulting in cytosolic release of lysosomal contents that are somehow sensed by the NLRP3 inflammasome."
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"It was reported in 2008 that alum-induced innate and adaptive immune responses were abrogated in NLRP3-deficient mice."
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"The BAs and their receptor TGR5 activation blocked NLRP3 inflammasome-dependent inflammasome, inducing LPS-induced systemic inflammation, alum-induced peritoneal inflammation and type2 diabetes related inflammasome through a TGR5–cAMP–PKA axis98."
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