IndraLab

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OTUB1 activates proteolysis. 4 / 4
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"OTUB1 exhibited tumor-promotive effects by interacting with beta-Catenin and reduced its protein degradation via UPP pathway."
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"Our analysis demonstrated that At-MABG therapeutic effects are associated with a molecular mechanism that occurs via the p53-p21 pathway, the Otub1 gene related to ubiquitin-mediated proteolysis and other representative highly ranked DEGs."
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"Therefore, OTUB1 promotes breast tumorigenesis in vivo and in vitro via blocking MYC protein degradation."
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"Among these upregulated proteins, there were OTUB1 (ubiquitin thioesterase), that prevents protein degradation and RAB6A and RAB7A (Ras-related protein Rab-6A and Rab-7A), involved in protein transpor[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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