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Translocation, Genetic activates USP6. 2 / 2

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"Notably, global DNA methylation analysis revealed that NOF and ABC presented distinct DNA methylation patterns, the latter being characterised by USP6 rearrangements caused by chromosomal translocations involving 17p13 locus [14]."

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"As many as 69% of primary ABCs demonstrate a characteristic clonal t(16;17) genetic translocation which can lead to an upregulation of the TRE17/USP6 oncogene [4]."

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IndraLab

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Translocation, Genetic activates USP6. 2 / 2

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