IndraLab

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USP13 activates Proteasome. 2 / 2

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"Notably, USP13 not only bound Bag6, but also interacted with MMS1 and alpha6, subunits of the proteasome (lane 5), further implicating USP13 in delivery pathways that targets substrates to the proteasome."

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"USP13 is upregulated in Alzheimer's disease (AD) and Parkinson's disease (PD), and USP13 knockdown via shRNA reduces neurotoxic proteins and increases proteasome activity in models of neurodegeneration."

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IndraLab

Statements

USP13 activates Proteasome. 2 / 2

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