IndraLab

Statements

USP13 activates Proteasome. 3 / 3
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"USP13 is upregulated in Alzheimer's disease (AD) and Parkinson's disease (PD), and USP13 knockdown via shRNA reduces neurotoxic proteins and increases proteasome activity in models of neurodegeneration."
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"Notably, USP13 not only bound Bag6, but also interacted with MMS1 and alpha6, subunits of the proteasome (lane 5), further implicating USP13 in delivery pathways that targets substrates to the proteasome."
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"In the study by Liu et al. [64], it was also shown that USP13 could regulate proteasome activity independently of Parkin, where USP13 expression, even with KD, could increase proteasome activity in α-synuclein-expressing cells irrespective of Parkin expression."
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