IndraLab

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ZUP1 inhibits IFNB1. 4 / 4
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"We previously found that the DUB activity of MERS-CoV PLpro suppresses IFN-β promoter activity upon activation of cellular innate immune signaling [9]."
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"These reports collectively indicate that coronaviruses express viral proteins with DUB activity to reduce IFN-β, which contributes to rapid viral growth and thus SARSassociated immunopathology."
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"For example, herpes simplex virus 1 encodes the largest tegument protein, UL36, which acts as a DUB to remove ubiquitin chains from TNF receptor associated factor 3 (TRAF3) and consequently inhibits IFN-β signaling [89•]."
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"Our results comparing various 3C pro mutants suggest that the DUB activity of 3C pro enables it to block induction of the IFN-β promoter and the Fig. 4 ."
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