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DNMT3A decreases the amount of KCNA2. 4 / 4
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"Moreover, mimicking the PCC-induced increase in dorsal horn DNMT3a via its genetic overexpression reduced the expression of Kv1.2 protein in the dorsal horn of naive rat."
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"Ube2b elevation could increase Kcna2 expression via suppressing DNMT3a."
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"Indeed, overexpression of DNMT3a through transduction of HSV-Dnmt3a in cultured DRG neurons of Dnmt3a mice reduced the level of Kcna2 mRNA, whereas knockdown of DNMT3a through transduction of AAV5-Cre in in vitro cultured DRG neurons of Dnmt3a mice substantially increased Kcna2 mRNA expression (Fig. 8d)."
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"Moreover, overexpression of DNMT3a via microinjection of AAV5-Dnmt3a reduced the level of Kv1.2 by 41% of the value in the naive group in L4/5 dorsal horn six weeks after microinjection (P < 0.01, Figure 6(d))."
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