IndraLab

Statements

IL17A activates USP25. 3 / 3
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"And the results demostrated that cytotoxic cytokines TNF-α and IFN-γ decreased, while IL-5 and IL-17a increased in Usp25 –/– mice ( Fig. 4 C)."
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"To investigate whether USP25 regulates IL-17-mediated airway inflammation, wild-type and Usp25 -/- mice were treated with PBS or IL-17 via intranasal injection, followed by analysis of bronchoalveolar lavage fluid (BALF) and lung inflammation."
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"Compared to wild-type cells, the expression of Cxcl1, Tnf and/or Il6 mRNA was enhanced in Usp25 -/- cells treated with IL-17 alone or in synergy with TNF but not with TNF alone (XREF_FIG)."
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