IndraLab
Statements
USP4 inhibits cell population proliferation. 20 / 22
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"In addition, by inducing USP4 overexpression (using a USP4 overexpression plasmid) or the knockdown of USP4 (by transfection with a USP4 shRNA plasmid), we found that USP4 inhibited cell proliferation in vitro."
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"To determine whether PDCD4 is involved in the anti-proliferative function of USP4, we further examined the role of PDCD4 in the USP4 induced inhibition of proliferation by knocking down PDCD4 using siRNA."
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"These results indicated that USP4 markedly inhibited breast cancer cell proliferation and colony forming ability."
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"Thus, in this study, we wished to determine whether PDCD4 is involved in the USP4 mediated inhibition of breast cancer cell proliferation."
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"These results indicated that USP4 markedly inhibited breast cancer cell proliferation and colony-forming ability."
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"As shown in XREF_FIG, the overexpression of USP4 significantly inhibited the proliferation of BT549 cells, whereas USP4 knockdown significantly promoted the proliferation of the MCF7 cells (XREF_FIG)."
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"These data demonstrate that USP4 suppresses the proliferation of breast cancer cells through the upregulation of PDCD4."
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"The findings showed that the expression of TGF-betaR1 and USP4 were increased in hypertrophic scar tissues and fibroblasts, and that down-regulating USP4 inhibited hypertrophic scar fibroblast proliferation and migration and induced cell apoptosis in vitro."
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"The Cell Counting Kit-8 (CCK-8) assay results showed that the proliferation of hypertrophic scar fibroblasts transfected with siUSP4 was significantly inhibited on the fifth and seventh day, indicating that down-regulation of USP4 could suppress the proliferation of hypertrophic scar fibroblasts."
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"USP4 inhibits breast cancer cell proliferation through the upregulation of PDCD4."
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"Moreover, USP4 elevation antagonized the OGD/R-induced microglia proliferation and activation by suppressing the NO levels and the expression of the microglial marker IBA-1."
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"These results indicate that PDCD4 is involved in the USP4 mediated inhibition of the proliferation of breast cancer cells."
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"These results suggest that USP4 inhibits breast cancer cell growth and proliferation in vivo."
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"To determine whether PDCD4 is involved in the anti-proliferative function of USP4, we further examined the role of PDCD4 in the USP4-induced inhibition of proliferation by knocking down PDCD4 using siRNA."
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sparser
"In addition, by inducing USP4 overexpression (using a USP4 overexpression plasmid) or the knockdown of USP4 (by transfection with a USP4 shRNA plasmid), we found that USP4 inhibited cell proliferation in vitro ."
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"USP4 inhibits breast cancer cell proliferation through the upregulation of PDCD4."