IndraLab

Statements

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"As shown in XREF_FIG, the overexpression of USP4 significantly inhibited the proliferation of BT549 cells, whereas USP4 knockdown significantly promoted the proliferation of the MCF7 cells (XREF_FIG)."
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"These results indicated that USP4 markedly inhibited breast cancer cell proliferation and colony forming ability."
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"In addition, by inducing USP4 overexpression (using a USP4 overexpression plasmid) or the knockdown of USP4 (by transfection with a USP4 shRNA plasmid), we found that USP4 inhibited cell proliferation in vitro."
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"We also demonstrate that USP4 inhibits breast cancer cell proliferation."
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"USP4 inhibits breast cancer cell proliferation."
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"These results indicate that PDCD4 is involved in the USP4 mediated inhibition of the proliferation of breast cancer cells."
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"Cai et al. showed that USP4 expression was significantly decreased in tumor tissues and knockdown of USP4 significantly promoted cell proliferation."
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"These data demonstrate that USP4 suppresses the proliferation of breast cancer cells through the upregulation of PDCD4."
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"In addition, by inducing USP4 overexpression (using a USP4 overexpression plasmid) or the knockdown of USP4 (by transfection with a USP4 shRNA plasmid), we found that USP4 inhibited cell proliferation in vitro ."
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"These results suggest that USP4 inhibits breast cancer cell growth and proliferation in vivo."
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"USP4 inhibits breast cancer cell proliferation through the upregulation of PDCD4."
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"Thus, in this study, we wished to determine whether PDCD4 is involved in the USP4 mediated inhibition of breast cancer cell proliferation."
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"To determine whether PDCD4 is involved in the anti-proliferative function of USP4, we further examined the role of PDCD4 in the USP4 induced inhibition of proliferation by knocking down PDCD4 using siRNA."
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"We also demonstrate that USP4 inhibits breast cancer cell proliferation."
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"USP4 inhibits breast cancer cell proliferation."
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"These results indicated that USP4 markedly inhibited breast cancer cell proliferation and colony-forming ability."
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"USP4 inhibits breast cancer cell proliferation through the upregulation of PDCD4."
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"To determine whether PDCD4 is involved in the anti-proliferative function of USP4, we further examined the role of PDCD4 in the USP4-induced inhibition of proliferation by knocking down PDCD4 using siRNA."
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"The Cell Counting Kit-8 (CCK-8) assay results showed that the proliferation of hypertrophic scar fibroblasts transfected with siUSP4 was significantly inhibited on the fifth and seventh day, indicating that down-regulation of USP4 could suppress the proliferation of hypertrophic scar fibroblasts."
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"The findings showed that the expression of TGF-betaR1 and USP4 were increased in hypertrophic scar tissues and fibroblasts, and that down-regulating USP4 inhibited hypertrophic scar fibroblast proliferation and migration and induced cell apoptosis in vitro."
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"The expression of USP4 is low in breast cancer, and the high expression of USP4 inhibits the proliferation of breast cancer cells and the occurrence and development of breast cancer, thus USP4 may be a potential tumor suppressor gene."
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"Moreover, USP4 elevation antagonized the OGD/R-induced microglia proliferation and activation by suppressing the NO levels and the expression of the microglial marker IBA-1."
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"USP4 is highly expressed in lung adenocarcinoma tissues, interference the expression of USP4 inhibits the proliferation of lung adenocarcinoma cells."
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"Apoptosis related protein Bax, Cleaved caspase-3 expression was increased, and Bcl2, caspase-3 expression was decreased (Fig. 3D), indicating that USP4 could promote cell apoptosis and inhibit cell proliferation."
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"Elevation of USP4 inhibits microglia proliferation and activation under OGD/R conditions."
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"Importantly, the up-regulation of USP4 suppressed microglia proliferation and activation under OGD/R conditions."
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