IndraLab

Statements

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"Similarly, we analyzed the levels of IFN-beta mRNA and our results also showed that the LPS of L. interrogans induced lower production of IFN-beta mRNA, compared to the LPS of E. coli (XREF_FIG)."
32790743
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"In accordance to the lack of LPS induced IFN-beta expression addition of a IFN-beta neutralizing antibody did not inhibit the LPS caused apoptosis (XREF_SUPPLEMENTARY)."
26863029
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"Indeed, Ifnb induction was slower, but more stable, in cells treated with P25 and LPS compared to free LPS."
28824614
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"It has been proposed that ERK activation is associated with suppression of LPS induced Ifnb and Il12b expression because it is necessary for induction of c-Fos, an inhibitor of both Ifnb and Il12b XREF_BIBR."
22427889
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"Therefore, we investigated whether HO-1 was involved in gAcrp mediated decrease in TLR4 expression and reduction in LPS stimulated IFN-beta and CXCL10."
20861358
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"CaMK inhibitor, STO609 inhibits LPS induced IFN-beta production."
23091438
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"On the other hand, the JAK-1 inhibitor marginally inhibited TNFalpha, LPS, IL-1beta, or Poly (I : C) induced induction of CCRL2, but almost completely blocked IFNgamma- or IFNbeta- dependent CCRL2 induction (XREF_FIG)."
22696441
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"LPS induced IFNbeta synthesis was also attenuated in monocytic CD11b + cells from D138N RIPK1 kinase-inactive mice (D138N RIPK1 or Ripk1 D138N and D138N) (XREF_FIG)."
28461567
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"Calyculin A added 1.5 h after LPS treatment greatly reduced accumulation of IP-10, IRF-1, and TNFR-2 mRNA, but not TNF-alpha, IL-1 beta, and IFN-beta mRNA."
7636205
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"This basal IRF-7 protein was completely abolished in either Ifnar1 -/- or Stat1 -/- macrophages, which corresponded with the loss of LPS stimulated IFN-beta induction in these macrophages."
32373120
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"Mechanism of inhibition of lipopolysaccharide induced interferon-beta production by 2-aminopurine."
22750230
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"LPS-induced IFN-b1 and CCL5/RANTES expression was also impaired in DDX3-knockdown HEK293 cells (Fig. 5A , lanes 9-10)."
26454002
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"One notable observation is that treatment of RAW 264.7 cells with bilirubin results in a marked reduction in LPS stimulated interferon-beta production, in the absence of an effect on cellular IL-6 release."
26163808
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"Thus, the Cpb1-C3-C3aR signaling axis of the complement system represents an important amplification mechanism for pro inflammatory signaling and caspase-11-mediated cell death during infectious disease.In contrast to the role of complement in amplifying caspase-11 expression during murine sepsis models [26], prostaglandin E 2 (PGE 2) is capable of potently inhibiting LPS induced IFNbeta production in murine BMDMs, which has the subsequent effect of significantly impairing LPS mediated caspase-11 expression [38]."
33546173
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"Loss of TRAF3 severely compromised LPS driven IFN-beta induction irrespective of prior TLR2 priming (XREF_FIG, left panel)."
23853595
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"This inhibition was, in part, attributable to impaired LPS stimulated secretion of interferon-beta, an autocrine co-factor for NO production."
10733102
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"BPI suppressed LPS mediated IFN-beta promoter activation as was in NF-kappaB activation."
17239348
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"Consistent with this, we have found that the TLR4 ligand LPS is a poor inducer of IRF3 activation compared to virus infection, and that LPS induced IFN-beta is severely impaired in IKKbeta -/- MEFs."
20610653
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"When studied after 24h of exposure, Ifnb mRNA levels markedly decreased in cells treated with free LPS, the mixture of LPS and NP, or the undiluted supernatant but, conversely, increased in cells incubated with the P25 and LPS fraction."
28824614
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"Unexpectedly, p204 deficiency led to significant defect in extracellular LPS signaling in macrophages, as demonstrated by dramatic reductions of LPS mediated IFN-beta and pro inflammatory cytokines."
29472103
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"In contrast, the ectopic expression of a constitutively active GSK3-beta (S9A) mutant severely attenuated the production of IFN-beta by LPS stimulated macrophages, as compared with empty vector transfected cells stimulated with LPS (XREF_FIG)."
18981097
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"Consistent with previous reports, LPS induced IFN-beta mRNA and protein (XREF_FIG) were not significantly decreased by MyD88 deficiency, whereas levels of TNF-alpha were dramatically inhibited in the MyD88 -/- macrophages (XREF_FIG)."
17562815
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"Enhanced Mkp-1 expression abolished IFN-beta induction by both LPS and E. coli but had little effect on the IFN-beta promoter activity in LPS-stimulated RAW264.7 cells ."
34039638
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"In contrast to the BMDMs expressing an E3 ligase defective Peli1 mutant [XREF_BIBR], the Peli1-KO BMDMs did not show significant reduction in LPS stimulated IFN-beta induction."
26131354
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"Our results showed that IL-6, IFN-beta, and IFN-gamma secretion from KCs was significantly increased after LPS stimulation and significantly inhibited by urantide pre-treatment of the LPS stimulated KCs."
27448985
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"This differential effect involves theFasadaptor FADDbecausewhilst LPS induced IL-6production increasedin FADD -/- murine embryonic fibroblasts, LPS induced IFNbeta production was significantly reduced in these cells."
30536547
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"Underlying this protective effect is the ability of suppressive ODN to bind to and prevent the phosphorylation of STAT1 and STAT4, thereby blocking the signaling cascade mediated by LPS induced IFN-beta and IL-12."
15814679
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"Serum IFN-beta levels from PP2ACalpha-knockout mice treated with LPS were also greater than those in controls."
27872207
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"These results suggested that 2-AP inhibited LPS induced IFN-beta production by preventing Toll/IL -1 receptor domain containing adaptor inducing IFN-beta (TRIF)-dependent signaling rather than myeloid differentiation factor (MyD) 88 dependent signaling, resulting in the inhibition of NO production."
15611612
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"CaMK inhibitor, STO609, treatment inhibits LPS induced IFN-beta production, which is correlated with the phosphorylation of interferon regulatory factor 3 (IRF3)."
23091438
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"It is also possible that the action of KC on STAT1 activation might be linked to the suppression of LPS induced IFN-beta, as IFN-beta is a principle STAT1 activating cytokine [XREF_BIBR]."
32290603
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"In contrast to the suggestion that p50 is responsible for Nfkb1 mediated inhibition of Ifnb, we have proposed that the ability of the C-terminal region of p105 to facilitate ERK activation is responsible for inhibition of LPS induced Ifnb expression XREF_BIBR."
22427889
eidos
"EcN chassis itself and LPS induced low levels of IFNbeta1 expression in a TLR4-dependent but STING-independent manner ( Fig. 3a and Supplementary Fig. 3a ) , suggesting that TLR4 activation may play a minor role in type I IFN induction in response to SYNB1891 ."
32483165
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"GSK3 inhibition also promotes LPS stimulated IFNbeta production via its ability to regulate c-Jun activity [XREF_BIBR]."
19836308
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"Artemisinin inhibits lipopolysaccharide induced interferon-beta production in RAW 264.7 cells : implications on signal transducer and activator of transcription-1 signaling and nitric oxide production."
23041519
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"LPS induced IFN-beta and IRF-1 gene expression were markedly suppressed by KE-758."
11409114
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"The decrease in LPS induced IFN-beta in the absence of Tpg was not statistically significant."
20660350
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"It has been demonstrated that HDAC3 deficient murine macrophages lack the ability to express inflammatory genes after LPS (lipopolysaccharide) stimulation, which is attributable to a secondary effect by the loss of LPS induced IFN-beta (interferone-beta) expression [XREF_BIBR]."
25793379
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"LPS also increased type I IFN-beta expression , which was suppressed by 2-DG and 6-AN and , therefore , is dependent on glycolysis and the pentose phosphate pathway ."
36009206
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"When HO-1 expression was knocked-down, the anti-inflammatory effects of gAcrp on LPS stimulated IFN-beta and CXCL10 were attenuated (XREF_FIG)."
20861358