IndraLab

Statements

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"In contrast to the suggestion that p50 is responsible for Nfkb1 mediated inhibition of Ifnb, we have proposed that the ability of the C-terminal region of p105 to facilitate ERK activation is responsible for inhibition of LPS induced Ifnb expression XREF_BIBR."
22427889
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"Artemisinin inhibits lipopolysaccharide induced interferon-beta production in RAW 264.7 cells : implications on signal transducer and activator of transcription-1 signaling and nitric oxide production."
28000518
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"Having shown that RSV initial attachment to cells can block polyI : C mediated IFN-beta induction Shingai et al. [112] further demonstrated that polyI : C- or LPS mediated IFN-beta production were inhibited by RSV G or soluble G (sG) proteins."
19007318
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"CaMK inhibitor, STO609, treatment inhibits LPS induced IFN-beta production, which is correlated with the phosphorylation of interferon regulatory factor 3 (IRF3)."
23091438
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"CaMK inhibitor, STO609 inhibits LPS induced IFN-beta production."
23091438
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"LPS induced IFN-beta and IRF-1 gene expression were markedly suppressed by KE-758."
11409114
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"In accordance to the lack of LPS induced IFN-beta expression addition of a IFN-beta neutralizing antibody did not inhibit the LPS caused apoptosis (XREF_SUPPLEMENTARY)."
26863029
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"In contrast to the BMDMs expressing an E3 ligase defective Peli1 mutant [XREF_BIBR], the Peli1-KO BMDMs did not show significant reduction in LPS stimulated IFN-beta induction."
26131354
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"This inhibition was, in part, attributable to impaired LPS stimulated secretion of interferon-beta, an autocrine co-factor for NO production."
10733102
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"As expected, the mRNA level of IRF3’s target gene IFN-β in TLR4 overexpressing BMs increased significantly at 2, 4, and 8 h after LPS treatment than that in WT BMs ( Fig. 5 B), and Dynasore treatment [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30522781
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"Unexpectedly, p204 deficiency led to significant defect in extracellular LPS signaling in macrophages, as demonstrated by dramatic reductions of LPS mediated IFN-beta and pro inflammatory cytokines."
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"GSK3 inhibition also promotes LPS stimulated IFNbeta production via its ability to regulate c-Jun activity [XREF_BIBR]."
19836308
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"Similarly, we analyzed the levels of IFN-beta mRNA and our results also showed that the LPS of L. interrogans induced lower production of IFN-beta mRNA, compared to the LPS of E. coli (XREF_FIG)."
32790743
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"When HO-1 expression was knocked-down, the anti-inflammatory effects of gAcrp on LPS stimulated IFN-beta and CXCL10 were attenuated (XREF_FIG)."
20861358
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"It is also possible that the action of KC on STAT1 activation might be linked to the suppression of LPS induced IFN-beta, as IFN-beta is a principle STAT1 activating cytokine [XREF_BIBR]."
32290603
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"LPS induced IFNbeta synthesis was also attenuated in monocytic CD11b + cells from D138N RIPK1 kinase-inactive mice (D138N RIPK1 or Ripk1 D138N and D138N) (XREF_FIG)."
28461567
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"Therefore, we investigated whether HO-1 was involved in gAcrp mediated decrease in TLR4 expression and reduction in LPS stimulated IFN-beta and CXCL10."
20861358
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"EcN chassis itself and LPS induced low levels of IFNbeta1 expression in a TLR4-dependent but STING-independent manner ( Fig. 3a and Supplementary Fig. 3a ) , suggesting that TLR4 activation may play a minor role in type I IFN induction in response to SYNB1891 ."
32483165
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"LPS also increased type I IFN-beta expression , which was suppressed by 2-DG and 6-AN and , therefore , is dependent on glycolysis and the pentose phosphate pathway ."
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"It has been proposed that ERK activation is associated with suppression of LPS induced Ifnb and Il12b expression because it is necessary for induction of c-Fos, an inhibitor of both Ifnb and Il12b XREF_BIBR."
22427889
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"Enhanced Mkp-1 expression abolished IFN-beta induction by both LPS and E. coli but had little effect on the IFN-beta promoter activity in LPS-stimulated RAW264.7 cells ."
34039638
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"Consistent with previous reports, LPS induced IFN-beta mRNA and protein (XREF_FIG) were not significantly decreased by MyD88 deficiency, whereas levels of TNF-alpha were dramatically inhibited in the MyD88 -/- macrophages (XREF_FIG)."
17562815
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"Consistently, immunosuppressive upstream regulator IL-10RA was activated ( Figure S3C ) while canonical proinflammatory TNFSF10, IFNB1 and IRF7 were inhibited by C498+LPS when compared to the LPS group ( Figure 3I )."
37122731
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"Underlying this protective effect is the ability of suppressive ODN to bind to and prevent the phosphorylation of STAT1 and STAT4, thereby blocking the signaling cascade mediated by LPS induced IFN-beta and IL-12."
15814679
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"As previously reported, Catalpalactone can inhibit the NO synthase (iNOS) expression and the production of NO, IL6 and tumor necrosis factor-α in the lipopolysaccharide-induced macrophage, and regulate the anti-inflammatory signaling, such as inhibiting STAT-1, IFN-β and IRF3 activation, to play a cytoprotecting role [21]."
39940010
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"This differential effect involves theFasadaptor FADDbecausewhilst LPS induced IL-6production increasedin FADD -/- murine embryonic fibroblasts, LPS induced IFNbeta production was significantly reduced in these cells."
30536547
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"Our results indicate that consecutive LPS injections attenuate the inflammatory response to sepsis by releasing IFN-β, resulting in the upregulation of TREM2 expression, which mediates the polarization of microglia from the M1 to M2 phenotype, reducing neuroinflammation."
36672106
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"When studied after 24h of exposure, Ifnb mRNA levels markedly decreased in cells treated with free LPS, the mixture of LPS and NP, or the undiluted supernatant but, conversely, increased in cells incubated with the P25 and LPS fraction."
28824614
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"Our results showed that IL-6, IFN-beta, and IFN-gamma secretion from KCs was significantly increased after LPS stimulation and significantly inhibited by urantide pre-treatment of the LPS stimulated KCs."
27448985
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"It has been demonstrated that HDAC3 deficient murine macrophages lack the ability to express inflammatory genes after LPS (lipopolysaccharide) stimulation, which is attributable to a secondary effect by the loss of LPS induced IFN-beta (interferone-beta) expression [XREF_BIBR]."
25793379
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"The inhibition is Toll-like receptor 4 (TLR4)-dependent as the TLR4 ligand, lipopolysaccharide (LPS), alone is sufficient to inhibit IFNbeta-mediated signaling and STm-infected, TLR4-deficient BMDMs do not exhibit inhibited IFNbeta signaling."
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"The inhibition is Toll-like receptor 4 (TLR4)-dependent as the TLR4 ligand, lipopolysaccharide (LPS), alone is sufficient to inhibit IFNbeta-mediated signaling and STm-infected, TLR4-deficient BMDMs do not exhibit inhibited IFNbeta signaling."
38496427
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"Consistent with this, we have found that the TLR4 ligand LPS is a poor inducer of IRF3 activation compared to virus infection, and that LPS induced IFN-beta is severely impaired in IKKbeta -/- MEFs."
20610653
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"The decrease in LPS induced IFN-beta in the absence of Tpg was not statistically significant."
20660350
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"Akt might therefore phosphorylate IRF-3 at a site other than Ser396, which is necessary for the nuclear translocation.In this study, we investigated the inhibitory mechanism of 2-AP on LPS-induced IFN[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22750230
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"Interestingly, in our study, overexpression of Ec SRECII significantly enhanced LPS-induced NF-κB and IFN-β signaling pathways, whereas knockdown of Ec SRECII resulted in the suppression of LPS-induce[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37257531
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"Interestingly, in this study, although the lack of EGF/EGF-like or the deletion of C-terminal domain had no inhibitory effect on the LPS-induced IFN-β signaling pathway, the deletion mutant of C-termi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the other hand, the JAK-1 inhibitor marginally inhibited TNFalpha, LPS, IL-1beta, or Poly (I : C) induced induction of CCRL2, but almost completely blocked IFNgamma- or IFNbeta- dependent CCRL2 induction (XREF_FIG)."
22696441
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"Artemisinin inhibits lipopolysaccharide induced interferon-beta production in RAW 264.7 cells : Implications on signal transducer and activator of transcription-1 signaling and nitric oxide production."
25707499
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"This basal IRF-7 protein was completely abolished in either Ifnar1 -/- or Stat1 -/- macrophages, which corresponded with the loss of LPS stimulated IFN-beta induction in these macrophages."
32373120
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"Indeed, Ifnb induction was slower, but more stable, in cells treated with P25 and LPS compared to free LPS."
28824614
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"LPS stimulation specifically inhibits IFNbeta signaling.."
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"Finally, to test the impact of reduced LPS-stimulated IFNB1 induction in the context of a Gram-negative bacterial challenge, we infected IFIT1-depleted and control macrophages with the bacterium B. cenocepacia."
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"Loss of TRAF3 severely compromised LPS driven IFN-beta induction irrespective of prior TLR2 priming (XREF_FIG, left panel)."
23853595
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"In contrast, the ectopic expression of a constitutively active GSK3-beta (S9A) mutant severely attenuated the production of IFN-beta by LPS stimulated macrophages, as compared with empty vector transfected cells stimulated with LPS (XREF_FIG)."
18981097
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"BPI suppressed LPS mediated IFN-beta promoter activation as was in NF-kappaB activation."
17239348
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"Calyculin A added 1.5 h after LPS treatment greatly reduced accumulation of IP-10, IRF-1, and TNFR-2 mRNA, but not TNF-alpha, IL-1 beta, and IFN-beta mRNA."
7636205
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"These results suggested that 2-AP inhibited LPS induced IFN-beta production by preventing Toll/IL -1 receptor domain containing adaptor inducing IFN-beta (TRIF)-dependent signaling rather than myeloid differentiation factor (MyD) 88 dependent signaling, resulting in the inhibition of NO production."
15611612
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"One notable observation is that treatment of RAW 264.7 cells with bilirubin results in a marked reduction in LPS stimulated interferon-beta production, in the absence of an effect on cellular IL-6 release."
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