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Caffeine inhibits NLRP3. 21 / 21
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"Caffeine inhibits activation of the NLRP3 inflammasome and regulates microglial polarization by antagonizing A2aR in hypoxic-ischemic WMD."
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"Caffeine inhibited the activation of NLRP3 inflammasome through autophagy to reduce neuroinflammation-mediated by microglia cells in experimental autoimmune encephalomyelitis (22)."
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"Caffeine has been found to inhibit the NLRP3 inflammasome in various laboratory cell and animal models."
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"The attenuation of microglia-mediated neuroinflammation in experimental autoimmune encephalomyelitis can be achieved by caffeine, which promotes autophagy and inhibits the activation of the NLRP3 inflammasome in microglia (19)."
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"Caffeine Citrate Protects Against Sepsis-Associated Encephalopathy and Inhibits the UCP2/NLRP3 Axis in Astrocytes."
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"Furthermore , caffeine was proven to significantly reduce NLRP3 expression and associated caspase cleavage as well as inhibit NLRP3 inflammasome activation by suppressing the mitogen-activated protein kinase ( MAPK ) / NF-kappaB signaling and therefore suppressed the secretion of IL-1beta and IL-18 in human derived THP-1 macrophages ( human monocytic cell line ) ( Guo et al ., 2015 ; Zhao et al ., 2019 ) ."
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"Caffeine Prevents NASH by Blocking the Activation of the NLRP3 Inflammasome Signaling Pathway."
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"The present study is the first to report that caffeine prevents the activation of the NLRP3 inflammasome and the increases in NLRP3, ASC, caspase 1, and IL-1β protein levels, which are consistent with results obtained from in vitro models [40,41], a model of lung damage [42], and experimental models of neuroinflammation [43,44]."
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"Based on the above findings, we assumed that caffeine inhibited NLRP3 inflammasome-specific cytokine secretion and that this effect was achieved by suppression of IL-1β gene expression."
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"Caffeine attenuates the activation of the NLRP3 inflammasome."
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"The authors demonstrated that caffeine treatment abolished NLRP3 inflammasome, decreased microglial Iba-1 activation and the pro-inflammatory M1 phenotype by downregulating CD86 and iNOS protein expression and inhibiting associated TNF-α and IL-1β secretion."
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"Caffeine inhibits NLRP3 inflammasome activity via the MAPK/NF-kappaB pathway."
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"In the same work, it was also shown that, in an in vitro model of neuroinflammation, caffeine was able to inhibit the activation of the NLRP3 inflammasome by promoting autophagy and by suppressing the mechanistic target of mTOR pathway [113]."
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"A recent study found that caffeine can reduce the activation of NLRP3 inflammasomes by inducing autophagy, thus alleviating the severity of EAE [118]."
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"In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome."
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"Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis."
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"Our study indicated that caffeine could inhibit the NLRP3 inflammasome in THP-1 macrophages by affecting MAPK/NF-κB signaling, in part by inhibiting A2aR-activated ROS generation (Figure 7)."
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"In our study, caffeine treatment of THP-1 macrophages followed by LPS/ATP stimulation downregulated NLRP3, Caspase 1 and IL-1β."
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"Caffeine inhibits activation of the NLRP3 inflammasome after hypoxic-ischemic WMD in neonatal rats."
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"Interestingly, recent animal studies showed that caffeine treatment inhibited activation of NLRP3 inflammasomes to reduce neuroinflammation mediated by microglia and improve myelin disorders in mice, and that inhibition of inflammasome activation by caffeine might be related to A2aR."
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"In the present study, we showed that caffeine inhibited activation of the NLRP3 inflammasome through A2aR, improved myelination, and reduced cognitive impairment."
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