IndraLab

Statements

Caffeine inhibits NLRP3. 6 / 6
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"Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis."
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"Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK and NF-kappaB signaling and A2aR associated ROS production in LPS induced THP-1 macrophages."
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"Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK and NF-kappaB and A2aR Signaling in LPS Induced THP-1 Macrophages."
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"Caffeine Citrate Protects Against Sepsis-Associated Encephalopathy and Inhibits the UCP2/NLRP3 Axis in Astrocytes."
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"Furthermore , caffeine was proven to significantly reduce NLRP3 expression and associated caspase cleavage as well as inhibit NLRP3 inflammasome activation by suppressing the mitogen-activated protein kinase ( MAPK ) / NF-kappaB signaling and therefore suppressed the secretion of IL-1beta and IL-18 in human derived THP-1 macrophages ( human monocytic cell line ) ( Guo et al ., 2015 ; Zhao et al ., 2019 ) ."
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"In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome."
34478049