Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

DDX58 activates CYLD. 2 / 3

| 2

➶

reach

"The data indicate that CYLD targets RIG-I as well as TBK1 for deubiquitination that leads to inactivation of the signaling."

18703349

➶

reach

"Based on the in vitro assessments, this miRNA directly targets cylindromatosis (CYLD) (a negative regulator of antiviral responses through removing lysine (K)-63-linked polyubiquitin of RIG-I), increases RIG-I ubiquitination and thereupon production of IFNs-I [109].7 hsa-miRNAs and SARS-CoV-2-induced interfering factors."

| PMC

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...