IndraLab

Statements

USP37 increases the amount of CDT1. 8 / 8
| 8
reach
"Moreover, previous evidence has shown that USP37 promotes the expression of CDT1."
33898105
reach
"If the overexpression of USP37 increases Cdt1 protein levels by affecting its ubiquitination- and proteasomal-dependent degradation, lack of USP37 should have the opposite consequence."
27296872
reach
"Also, overexpression of an siRNA resistant version of Flag-USP37 rescued the drop in Cdt1 levels caused by USP37 depletion ( Supplemental Figure 4A )."
27296872
reach
"Using an overexpression screen of 78 human ubiquitin and ubiquitin-like hydrolases, Perez et al. reported that USP37 increases CDT1 levels when cells are exposed to DNA-damaging agents while USP37 depletion with siRNA decreases CDT1 protein levels [48]."
| PMC
reach
"The results revealed that the overexpression of USP37 increased CDT1 protein levels and USP37 silencing decreased CDT1 expressions (XREF_FIG I and 5J)."
33898105
reach
"USP37 overexpression increases Cdt1 protein levels and knock down of this deubiquitinating enzyme (DUB) leads to lower Cdt1 levels."
27296872
reach
"To understand whether the regulation of CDT1 expression by USP37 plays a role in lung cancer cell growth and invasion, the expressions of miR-320b and/or CDT1 in lung cancer cells (A549 and H1650) were altered."
33898105
reach
"The results illustrated that USP37 knockdown significantly reduced CDT1 protein levels while lysosomal inhibitor (MG132) preserved the CDT1 protein (XREF_FIG M)."
33898105