IndraLab

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USP37 increases the amount of CDT1. 5 / 5
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"Using an overexpression screen of 78 human ubiquitin and ubiquitin-like hydrolases, Perez et al. reported that USP37 increases CDT1 levels when cells are exposed to DNA-damaging agents while USP37 depletion with siRNA decreases CDT1 protein levels [48]."
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"Moreover, previous evidence has shown that USP37 promotes the expression of CDT1."
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"The results revealed that the overexpression of USP37 increased CDT1 protein levels and USP37 silencing decreased CDT1 expressions (XREF_FIG I and 5J)."
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"To understand whether the regulation of CDT1 expression by USP37 plays a role in lung cancer cell growth and invasion, the expressions of miR-320b and/or CDT1 in lung cancer cells (A549 and H1650) were altered."
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"The results illustrated that USP37 knockdown significantly reduced CDT1 protein levels while lysosomal inhibitor (MG132) preserved the CDT1 protein (XREF_FIG M)."
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