IndraLab

Statements

USP18 inhibits NOTCH1. 3 / 3
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"Second, USP18 overexpression reduces the K48 linked ubiquitination level of Notch1, whereas USP18 silencing significantly increases the Notch1 K48 linked ubiquitination."
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"Moreover, USP18 overexpression reduced the K48 linked ubiquitination level of Notch1, whereas USP18 silencing significantly increased Notch1 K48 linked ubiquitination (XREF_FIG - XREF_FIG)."
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"Indeed, we found here that USP18 silencing could increase the turnover rate of Notch1 in the presence of cycloheximide (CHX) (XREF_FIG and XREF_FIG)."
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