IndraLab

Statements

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"Similarly, MicroRNA 32 (miR-32) can directly target the 3′-untranslated region (3′-UTR) of OTUD3 to inhibit OTUD3 expression, which can promote proliferation and motility of colon cancer cells and inhibits apoptosis (Jin et al., 2019)."
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"In cell lines both derived from blood/lymphocyte and other tissues, the CERES scores (32) were significantly lower than 0 (Fig. 3G), suggesting knockout of OTUD3 would broadly reduce the proliferation rate of various cell lines."
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"OTUD3 could rescue the accelerated cell proliferation caused by OTUD3 knockdown, but the inactive enzyme mutant OTUD3 could not inhibit the accelerated cell proliferation, indicating that regulation of the effect of OTUD3 on cell proliferation depends on its ubiquitinase activity (Fig. 6b)."
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"As OTUD3 plays a promoting role in lung tumorigenesis by stabilizing GRP78, inhibitors of OTUD3 should inhibit the proliferation of NSCLC cells [26]."
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"However, in lung cancer, OTUD3 promotes tumour proliferation and metastasis and inhibits apoptosis through deubiquitination of GRP78 protein and is closely related to drug resistance (163)."
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"The results revealed that stable expression of OTUD3 inhibited HeLa cell proliferation, OTUD3 knockout promoted proliferation, and reintroduction of wild-type OTUD3 into OTUD3-KO cells restored the enhanced proliferation ability."
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"Mechanistically, OTUD3 promotes the proliferation of lung adenocarcinoma through deubiquitylation and stabilization of GRP78 [2]."
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"Finally, ACTN4 was found to be essential for OTUD3 mediated HCC proliferation and metastasis in vitro and in vivo."
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"In Bronchopulmonary dysplasia (BPD) mouse, miR-34c-5p negatively targeted OTUD3 which enhanced proliferation, angiogenesis, and migration in human pulmonary microvascular endothelial cells (HPMECs) (He et al., 2023) (Figure 3A)."
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