IndraLab

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USP9X deubiquitinates EPS15. 5 / 7
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"USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15."
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"USP9X has been reported to simultaneously regulate endocytosis of the EGFR by deubiquitinating its endocytic adaptor Eps15 and ubiquitin ligase Itch in tumor cell lines (17, 18, 40)."
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"Interestingly, recent findings further demonstrate that EPS15 de-ubiquitination by USP9X affects EGFR internalization and its trafficking to lysosomes."
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"These include USP9x, which deubiquitylates EPS15 to relieve its autoinhibition and thereby promotes trafficking and downregulation of ubiquitylated receptors (Savio et al., 2016) (Fig. 1B)."
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"USP9X has been shown to regulate EGFR endocytosis in tumor cell lines by deubiquitinating its endocytic adaptor Eps15 and ubiquitin ligase Itch [31]."
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