IndraLab

Statements

Rutin inhibits RELA. 6 / 6
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"It was shown that troxerutin suppresses p65 by downregulating signal transducers and activation of transcription 3 (STAT3) and sensitizes cancer cells to 5-FuU apoptosis through Bcl-2 prevention."
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"Moreover, troxerutin notably suppressed nuclear factor-kappaB (NF-kappaB) p65 transcriptional activation and release of inflammatory cytokines in HFD treated mouse livers."
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"This study revealed that rutin can decrease inducible nitric oxide synthase ( iNOS ) gene and protein expression levels , effectively increase IkappaB gene expression , reduce toll-like receptor 4 ( TLR4 ) , myeloid differentiation factor 88 ( MyD88 ) , tumour necrosis factor receptor-associated factor 6 ( TRAF6 ) and p65 gene expression and inhibit the phosphorylation of IkappaB and p65 and the proteins expression of TLR4 , MyD88 and TRAF6 ."
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"However, rutin treatment down-regulated the p-NF-κB p65 protein expression ratios in the kidney tissues of IRR-, MT-, and IRR/MT-intoxicated animals (Fig. 9)."
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"Because NF-κB plays a pivotal role in the synthesis of nitric oxide, as well as pro-inflammatory cytokines, such as IL-1β and TNF-α, and other important pro-inflammatory mediators the effects of Iso a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, troxerutin has been shown to block the endoplasmic reticulum stress pathway, and inhibit the activation of pro-inflammatory protein kinases and cytokines (JNK1/IKKb/NF-κB, p65, COX2 and i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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