IndraLab

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Rutin inhibits RELA. 3 / 3
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"It was shown that troxerutin suppresses p65 by downregulating signal transducers and activation of transcription 3 (STAT3) and sensitizes cancer cells to 5-FuU apoptosis through Bcl-2 prevention."
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"This study revealed that rutin can decrease inducible nitric oxide synthase ( iNOS ) gene and protein expression levels , effectively increase IkappaB gene expression , reduce toll-like receptor 4 ( TLR4 ) , myeloid differentiation factor 88 ( MyD88 ) , tumour necrosis factor receptor-associated factor 6 ( TRAF6 ) and p65 gene expression and inhibit the phosphorylation of IkappaB and p65 and the proteins expression of TLR4 , MyD88 and TRAF6 ."
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"Moreover, troxerutin notably suppressed nuclear factor-kappaB (NF-kappaB) p65 transcriptional activation and release of inflammatory cytokines in HFD treated mouse livers."
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