IndraLab

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SPP1 activates ITGB1. 5 / 6
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"Taken together, our results indicate that OPN activates CD29 on tumor-reactive CD8 + T cells in an MHCII-deficient TME, resulting in prolonged NFAT2 signaling and eventually, TOX-mediated CD8 + T cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Notably, a recent study uncovered that osteopontin (OPN) (encoded by SPP1) would activate CD29 on tumor-reactive CD8 T cells and result in TOX-mediated CD8 T cells dysfunction."
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"We also found that SPP1 can modulate Integrin beta1 (ITGB1)/focal adhesion kinase (FAK)/AKT pathway."
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"Taken together, our results indicate that OPN activates CD29 on tumor-reactive CD8 + T cells in an MHCII-deficient TME, resulting in prolonged NFAT2 signaling and eventually, TOX-mediated CD8 + T cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36638785
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"OPN directs MSC fate choice towards osteogenesis and away from adipocytic differentiation through binding the integrin heterodimer α V β 1 (CD51/CD29) on MSCs."
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