IndraLab

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Acetic acid inhibits NLRP3. 11 / 11
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"In addition, acetate reduces the activation of NLRP3 through ubiquitination and autophagy and plays an anti-inflammatory role in peritonitis and endotoxemia models."
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"Acetate Downregulates the Activation of NLRP3 Inflammasomes and Attenuates Lung Injury in Neonatal Mice With Bronchopulmonary Dysplasia."
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"There is evidence that ketone bodies, beta-hydroxybutyrate (BHB), but not acetoacetate (AcAc) or the structurally related SCFAs, butyrate and acetate, suppress activation of the Nlrp3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids XREF_BIBR, XREF_BIBR."
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"We found that acetate downregulated the expression levels of NLRP3 related proteins, alleviated lung inflammation, and improved simplification of alveoli."
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"XREF_BIBR In addition, in a murine model of pulmonary fibrosis and inflammation induced by polyhexamethylene guanidine phosphate, OA acetate effectively reduced elevation of cytokines and the activation of the NLRP3 inflammasome."
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"Bamboo Vinegar Decreases Inflammatory Mediator Expression and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Protein Kinase C-alpha and delta Activation."
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"It can be concluded that after activation of GPR43 by acetate, NLRP3 activation is inhibited by decreasing Ca2 +."
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"In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes."
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"Further mechanistic investigation showed that vinegar and acetic acid reduce ulcerative colitis inflammation in mice by inhibiting Th1 and Th17 responses, NLRP3 inflammasome, and activation of MAPK signaling [49]."
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"With respect to the effects of SCFAs, Wang et al. reported that the Nlrp3 inflammasome was activated by sodium butyrate in db/db mice XREF_BIBR, while Ho et al. demonstrated that bamboo vinegar decreases inflammatory mediator expression and Nlrp3 inflammasome activation by inhibiting reactive oxygen species (ROS) generation and protein kinase C-alpha and delta activation both in vitro and in vivo XREF_BIBR."
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"A study by Youm et al. showed that the NLRP3 inflammasome activation was inhibited by the ketone body beta-hydroxybutyrate (BHB) but not by acetoacetate or by related short-chain fatty acids butyrate and acetate [XREF_BIBR]."
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