IndraLab

Statements

CYLD inhibits Neoplasms. 16 / 18
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"Recently, tumor suppressors such as ARF and CYLD have been shown to inhibit NF-κB, contributing to their antitumor activities."
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"CYLD deficiency enhances anti-PD-1-mediated tumor regression."
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"Regarding TC, with more aggressive behavior, several tumor suppressors including CYLD, CBFB, CDH1, CDH11, CTCF, and ZFHX3 was found, as well as a higher Tumor Mutational Burden (TMB) compared to thymomas (22)."
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"Thus , the up-regulation of CYLD activity is associated with neurodegenerative diseases , whereas the down-regulation of CYLD causes cancers ."
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"CYLD inhibited several tumor signal pathways such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), Wnt, and Akt pathways by removing Lysine (K)63-linked poly-ubiquitin chains from important effectors in these pathways like NEMO, TRAF2, TRAF6, RIPK1, Dvl, and Akt."
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"Frequent focal losses tended to center at or near known tumor suppressors in MM, such as GFI1, FAM46C, CDKN2C, ARID1B, NKX3-1, CDKN2A/B, BIRC2/3, CDKN1B, RB1, TRAF3, and CYLD, while focal gains were at or near oncogenes including MYC, CCND1, and TXNDC5 (Fig. 1b) ."
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"Parallel work performed on in vitro SMZL models treated with the demethylating agent decitabine shows the latter is, at least partially, able to reverse the CIMP-positive phenotype, re-expressing tumo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Massoumi et al. revealed that, in malignant melanoma, loss of CYLD expression promoted tumor progression via increased tumor cell proliferation and migration, and patients with lower CYLD expression exhibited significantly shorter overall survival [15]."
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"Contrary to common belief, lack of CYLD, which would also cause concomitant loss of CYLD-mediated oncogenic activity, may limit tumor growth and prevent progression to malignancy."
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"In order to determine if CYLD knockdown enhances tumor growth and DDP resistance, we generated a xenograft model in BALB/C nude mice with OVCAR3-shNC and OVCAR3-shCYLD (Fig. 7A)."
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"The results indicated that CYLD knockdown greatly increased the tumor growth of OVCAR3 cells following DDP treatment (Fig. 7B and 7D)."
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"Moreover, Snail was found to negatively regulate the transcription levels of CYLD, which promotes tumor progression in malignant melanoma [54] ."
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"Genetic deletion of Spata2 and CYLD enhances infiltration of anti-tumoral CXCR3 T/NK cells and anti-PD-1-mediated tumor regression in vivo."
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"The results showed that CYLD overexpression significantly inhibited tumor growth in A2780-DDP cells after DDP treatment (Fig. 8B and 8C)."
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"Meanwhile, we validated that the overexpression of CYLD or treatment with miR-588 inhibitor repressed the tumor growth in nude mice, while the depletion of CYLD rescued miR-588 inhibitor-reduced tumor growth in the model (Figure 7E and F)."
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"This cluster also displays losses on chromosome 16, including the tumor suppressors CYLD and TSC2, and the DNA repair gene PALB2, as well as reduced expression of all three."
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