IndraLab

Statements

AKT phosphorylates CDKN1B on S10. 20 / 29
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"His Akt phosphorylated p27 at S10 as determined by phospho specific S10 antibody and the reaction was inhibited by an Akt inhibitor."
16780593
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"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30], or JNK (this study and [20])."
22014979
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"Akt directly binds to and phosphorylates p27 Kip1 at three residues, Ser10, Thr187, and Thr198 [XREF_BIBR - XREF_BIBR]."
22481935
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"The inhibition of the PI3K/AKT pathway in thyroid cancer cells coordinately increased p27 kip1 nuclear relocalization and reduced p27 kip1 phosphorylation at T157 and T198, whereas it did not affect p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15743786
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"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30] , or JNK (this study and [20] )."
22014979
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"Ras also signals through PI3K to activate Akt, which in turn can phosphorylate p27 at multiple sites including Ser10, Thr157 (in human but not in mouse), and Thr198 (Thr197 in the mouse), each of which has been shown to promote nuclear to cytoplasmic shuttling."
19648963
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"In both cases we found that Akt phosphorylates p27 at serine 10."
16780593
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"Phosphorylation of p27 at S10 is mediated by AKT, KIS, CDK5 and CDK16 kinases whereas T187 phosphorylation is mediated by CDK2."
32086342
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"The cyclin-dependent kinase 2 (Cdk2)-Cyclin E complex is responsible for phosphorylation of p27 at Thr187 ( Sherr and Roberts, 1999; Lee and Kay, 2007 ), while Akt phosphorylates p27 on Ser10, Thr157,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21855543
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"AKT phosphorylates p27 Kip1 at Ser10, Thr157, Thr187, and Thr198 [28] and in every case it is associated with nuclear export of p27 Kip1 ."
15588951
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"In addition, TM4SF5 expression causes AKT activation, which in turn causes phosphorylation of p27 Kip1 Ser10 for its cytosolic translocation, where it can regulate RhoA activity for morphological change and migratory function [XREF_BIBR]."
24748857
sparser
"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30] , or JNK (this study and [20] )."
22293298
sparser
"AKT phosphorylates p27 Kip1 at Ser10, Thr157, Thr187, and Thr198 [28] and in every case it is associated with nuclear export of p27 Kip1 ."
15588951
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"Our data further demonstrated that the phosphorylated p27 (phospho-p27) at Thr 187 is localized in the nuclei, thus confirming that the protein is degraded in the nuclei.Recent studies demonstrated th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16769055
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"PKB then phosphorylates p27 Kip1 at ser10 and thr157."
19214781
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"Phosphorylation of p27 Kip1 at Thr187 is the only p27 Kip1 covalent modification recognised and bound by ubiquitin ligase for subsequent degradation, whereas phosphorylation of p27 Kip1 at Ser10, whic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21571010
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"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30], or JNK (this study and [20])."
22293298
sparser
"As shown in xref , when the cell enters the G1 phase, the phosphorylation of p27 on Ser10 by AKT (protein kinase B), CDK5 or KIS (kinase interacting stathmin) promotes the exportation of p27 from the nucleus to the cytoplasm by CRM1 (chromosome region maintenance 1), a carrier protein for nuclear export [ xref ]."
35163135
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"AKT phosphorylates p27 at multiple residues including S10, T157, and T198, which mediates p27 stability and/or localization depending on the cellular context."
22733130
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"PKB then phosphorylates p27 Kip1 at ser10 and thr157."
19214781