IndraLab

Statements

AKT phosphorylates CDKN1B on S10. 20 / 21
1 1 | 9 5 4
rlimsp
"Activation of RalBP1 leads to cytoplasmic accumulation of p27 by a mechanism that requires phosphorylation of Ser-10 on p27 by Akt."
23576547
reach
"His Akt phosphorylated p27 at S10 as determined by phospho specific S10 antibody and the reaction was inhibited by an Akt inhibitor."
16780593
sparser
"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30] , or JNK (this study and [20] )."
22293298
reach
"AKT phosphorylates p27 at multiple residues including S10, T157, and T198, which mediates p27 stability and/or localization depending on the cellular context."
22733130
sparser
"PKB then phosphorylates p27 Kip1 at ser10 and thr157."
19214781
reach
"Akt directly binds to and phosphorylates p27 Kip1 at three residues, Ser10, Thr187, and Thr198 [XREF_BIBR - XREF_BIBR]."
22481935
rlimsp
"The results (Figure 9) demonstrate that both inhibitors abrogate the Ral-mediated effects, suggesting that the mechanisms by which RalBP1 induces Ser-10 phosphorylation on p27 and its accumulation in the cytoplasm proceeds via activation of Akt."
23576547
rlimsp
"Our results reveal a delicate balance between the RalBP1 pathway, which mediates p27 translocation to the cytoplasm and requires p27 phosphorylation at Ser-10 by Akt, and the PLD1 pathway, which is independent of Ser-10 phosphorylation and supports nuclear localization of p27."
23576547
signor
"Identification of p27kip1phosphorylation sites revealed that akt phosphorylated p27kip1at ser10(fig.4). Therefore, akt might participate in nuclear export of p27kip1as well as p27kip1degradation. Moreover, akt might be one of the unidentified ser10kinases."
12042314
reach
"Phosphorylation of p27 at S10 is mediated by AKT, KIS, CDK5 and CDK16 kinases whereas T187 phosphorylation is mediated by CDK2."
32086342
sparser
"In both cases we found that Akt phosphorylates p27 at serine 10."
16780593
sparser
"As shown in xref , when the cell enters the G1 phase, the phosphorylation of p27 on Ser10 by AKT (protein kinase B), CDK5 or KIS (kinase interacting stathmin) promotes the exportation of p27 from the nucleus to the cytoplasm by CRM1 (chromosome region maintenance 1), a carrier protein for nuclear export [ xref ]."
35163135
reach
"In addition, TM4SF5 expression causes AKT activation, which in turn causes phosphorylation of p27 Kip1 Ser10 for its cytosolic translocation, where it can regulate RhoA activity for morphological change and migratory function [XREF_BIBR]."
24748857
reach
"Ras also signals through PI3K to activate Akt, which in turn can phosphorylate p27 at multiple sites including Ser10, Thr157 (in human but not in mouse), and Thr198 (Thr197 in the mouse), each of which has been shown to promote nuclear to cytoplasmic shuttling."
19648963
reach
"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30], or JNK (this study and [20])."
22293298
phosphoelm
No evidence text available
16780593
reach
"PKB then phosphorylates p27 Kip1 at ser10 and thr157."
19214781
sparser
"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30] , or JNK (this study and [20] )."
22014979
reach
"Previous reports and the current study suggest that p27 Kip1 is phosphorylated at Ser10 by Akt, KIS [21,23,30], or JNK (this study and [20])."
22014979
rlimsp
"Although Akt also phosphorylated p27(Kip1) at Ser(10) and Thr(187), these two sites were not involved in the binding to 14-3-3 proteins."
12042314