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Dexamethasone inhibits NFKB1. 7 / 9
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"We thus inhibited NF-κB p50 activity with andrographolide or knocked down CTCF with its specific siRNA, and found that high-dose dexamethasone-mediated osteoclastogenesis was blocked once NF-κB p50 activity was inhibited, and was not affected by knockdown of CTCF (Fig. 6c, d)."
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"It was clearly observed that the exposure to dexamethasone reduces NFkB activation."
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"NF-kb is a master regulator of the immune function and is antagonized by dexamethasone, which has been demonstrated to improve outcomes in severe COVID-19 cases (52)."
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"Dexamethasone suppressed NF-KB activation in the steroid- resistant patients as well as in the steroid responsive patients, but steroid induced inhibition of another transcription factor (activation p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"By comparison, dexamethasone, a glucocorticoid agonist, suppressed NFkB-signaling in Muller glia in damaged retinas, in addition to reducing numbers of dying cells and the accumulation of reactive microglia."
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"In this study we demonstrate that dexamethasone, which reduces the production of ceramide, significantly inhibits TNF-alpha-induced activation of NF-KB, c-Jun N-terminal kinase, also known as stress activating protein kinase, caspase-3-like cysteine protease, redistribution of cytochrome c, and apoptosis in MC3T3E1 osteoblasts."
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"In airway epithelial cell lines, we confirmed that NFKB1 and IRF1 were consistently down-regulated by dexamethasone treatment at 6 hours."
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