IndraLab

Statements

USP7 decreases the amount of FOXP3. 7 / 7
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"Ectopic expression of USP7 decreased FOXP3 polyubiquitination and increased FOXP3 expression."
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"USP7 is upregulated in Treg cells, and the ectopic expression of USP7 decreases Foxp3 polyubiquitylation and increases Foxp3 expression."
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"Ectopic expression of USP7 decreases the polyubiquitination of Foxp3 and increases the expression level of Foxp3 protein."
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"On the contrary, USP7 expression decreased polyubiquitination of Foxp3 and enhanced Foxp3 expression (30)."
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"However, Usp7 deficiency caused minor changes in the expression of T-bet, GATA3, RORγt, and Foxp3 in Th2 cells (SI Appendix, Fig. S3F)."
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"The knockdown of USP7 decreased the levels of endogenous FOXP3 and diminished the Treg suppressive activity while ectopic expression of USP7 increased FOXP3 expression by preventing its degradation."
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"USP7 increases the quantity and function of Tregs to maintain self-tolerance and reduce the inflammation of IBD by directly deubiquitinating and enhancing the expression of Foxp3 (63)."
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