IndraLab

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USP22 decreases the amount of H2Bub1. 4 / 4
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"To investigate whether the observed decrease in H2Bub1 levels upon GANP depletion are the result of an increased DUB activity, we tested whether the concomitant depletion of the three USP22-related DUBm-s through ENY2 KD or ATXN7L3 KD would restore normal H2Bub1 levels."
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"As expected, USP22 depletion led to increased H2Bub1 levels, as well as reduced Sirt1 and PD-L1 levels ( Fig. 3 C – E)."
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"Functionally, USP22 depletion led to increased protein level of H2Bub1, reduced PD-L1 and Sirt1in HCT116 cells."
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"However, while USP22 is capable of deubiquitinating H2B in vitro [36,53,60] and USP22 knockdown increases H2Bub1 levels on the IRF1 gene [18] , none of the published reports demonstrated a significant[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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