IndraLab

Statements

USP22 activates TP53. 4 / 4
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"Several studies demonstrated that USP22 silencing could activate p53. xref , xref Because USP22, Ube2d4, and Ube3b were important downstream genes of YWHAZ, we infer that YWHAZ downregulates p53 by activating USP22, Ube2d4, and Ube3b, which make P53 ubiquitination and lead to its proteasomal degradation."
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"Silencing of USP22 promotes human retinoblastoma cell apoptosis by inhibiting TERT and P53 pathway 36."
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"USP22 promotes hypoxia induced HCC stemness by a HIF1alpha and USP22 positive feedback loop on TP53 inactivation."
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"USP22 promotes hypoxia induced hepatocellular carcinoma stemness by a HIF1alpha and USP22 positive feedback loop upon TP53 inactivation."
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