IndraLab

Statements

USP22 activates TP53. 8 / 8
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"Silencing of USP22 promotes human retinoblastoma cell apoptosis by inhibiting TERT and P53 pathway 36."
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"Since Sirt1 is a suppressor for p53 functions, it is possible that USP22 promotes cell proliferation and suppresses apoptosis through regulation of Sirt1 to antagonize p53 function."
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"Usp22 promotes oncogenic c-Myc activation as well as indirectly antagonizes the tumor-suppressive function of p53, and clearly diminishes tumor growth in in vitro and in vivo LLC1 models (55)."
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"USP22 can also suppress apoptosis and promote cell proliferation by antagonizing p53 function through the regulation of SIRT1[29,30]."
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"USP22 promotes hypoxia induced hepatocellular carcinoma stemness by a HIF1alpha and USP22 positive feedback loop upon TP53 inactivation."
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"USP22 promotes hypoxia induced HCC stemness by a HIF1alpha and USP22 positive feedback loop on TP53 inactivation."
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"Several studies demonstrated that USP22 silencing could activate p53. xref , xref Because USP22, Ube2d4, and Ube3b were important downstream genes of YWHAZ, we infer that YWHAZ downregulates p53 by activating USP22, Ube2d4, and Ube3b, which make P53 ubiquitination and lead to its proteasomal degradation."
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"In TP53-mutated hepatocellular carcinoma, USP22 and HIF-1α promote the stabilization of each other, forming a positive feedback loop (29)."
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