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USP18 increases the amount of IL2. 2 / 2

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"In response to T cell receptor engagement, USP18 deficient T cells exhibit hyperactivation of NF-kappaB and NFAT and produce increased levels of IL-2 compared with the wild-type controls."

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"In our experiments, we found that USP18 deficient naive CD4 + T cells produced increased amounts of IL-2 compared with the WT counterparts stimulated with anti-CD3 and CD28 or under Th17 polarizing conditions."

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IndraLab

Statements

USP18 increases the amount of IL2. 2 / 2

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