IndraLab

Statements


USP18 decreases the amount of CXCL10. 3 / 3
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"These results were confirmed in primary rat beta cells (XREF_FIG) in which USP18 inhibition upregulated CXCL10, CCL5 and IL-15 mRNA expression."

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"We demonstrated that USP18 deficient cells have increased expression of IFIT1, IFIT2, IFIT3, IFITM1, IFITM2, CXCL9, CXCL10, ISG15, and MX2 after treatment with exogenous IFN‐β."

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"We demonstrated that USP18 deficient cells have increased expression of IFIT1, IFIT2, IFIT3, IFITM1, IFITM2, CXCL9, CXCL10, ISG15, and MX2 after treatment with exogenous IFN-. Many of these genes have been previously shown to restrict HIV-1 replication."