IndraLab

Statements

KCNMA1 activates autophagy. 4 / 4
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"In the context of pharyngeal keratinocytes, GAS secretes SLO, which triggers autophagy – a process where the cell attempts to digest internalized material."
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"SLO induces autophagy, and cytosolic GAS are contained within an LC3-positive, membrane-bound structure called GAS-containing autophagosome-like vacuoles (GcAVs) [47] ."
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"Our results showed that SLO activates autophagy in wild-type cells, as indicated by the increase in SQSTM1 degradation as well as LC3B-II upregulation."
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"To delineate the cellular process that is triggered by SLO and SLS delivery the involvement of autophagy, apoptosis, and necrosis that are affected by the hemolysin toxins and were shown to be linked to GAS pathogenesis was examined."
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