IndraLab

Statements

USP22 increases the amount of PALB2. 5 / 5
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"USP22 modulates PALB2 and BRCA2 levels to promote chemoresistance in lung adenocarcinoma."
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"To determine whether USP22 is modulating PALB2 and BRCA2 protein levels at the transcriptional level we performed qPCR of BRCA2 and PALB2 with and without USP22 knockdown after 48 hours (Figure S1b)."
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"To further validate USP22 was modulating and stabilizing BRCA2 and PALB2 levels at the translational level, cells were depleted of USP22 again with and without treatment of the proteasome inhibitor MG132 to see if this could rescue PALB2 and BRCA2 levels in a USP22 knockdown background (Figure S1c)."
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"Lastly, we show USP22 positively regulates BRCA2 and PALB2 levels at the protein level."
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"Our study reveals USP22 positively regulates PALB2 and BRCA2 levels at the translational level."
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