IndraLab

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"Here we found that USP19 overexpression significantly promotes the secretion of soluble and aggregated misfolded TDP-43, requiring both ER anchoring and ubiquitin peptidase activity."
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reach
"Notably, our recent work further unraveled that the deubiquitinating enzyme USP19 enables activation of its co-localized NFE2L1 in proximity to the ER and, in turn, NFE2L1 in close cooperation with NFE2L2/Nrf2 can tightly govern the transcriptional expression of USP19 and other DUBs insomuch as to form a positive feedback regulatory circuit [49]."
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