IndraLab

Statements

YOD1 binds SNCA. 10 / 10
4 | 6
sparser
"However, since the interaction between YOD1 and α-synuclein has not been elucidated, the current study investigated the relationship between YOD1 and α-synuclein."
36682332
sparser
"We found that YOD1 directly interacts with α-synuclein and deubiquitinates K6-, K11-, K29-, K33-, and K63-linked polyubiquitin chains on α-synuclein."
36682332
sparser
"YOD1 directly interacts with α-synuclein and removes various polyubiquitin chains (K6, K11, K29, K33, and K63) through deubiquitination, thus regulating protein stability and reducing aggregation."
40555982
biogrid
No evidence text available
30021006
sparser
"Next, we performed the GST pull-down assay to check the direct interaction between YOD1 and α-synuclein, and found that GST-YOD1 precipitates α-synuclein ( Fig. 1 B)."
36682332
sparser
"These results indicate the direct interaction between YOD1 and α-synuclein."
36682332
biogrid
No evidence text available
36682332
biogrid
No evidence text available
36682332
biogrid
No evidence text available
36682332
sparser
"Mechanistically, OTUD2 directly interacts with α-synuclein to cleave K6-, K11-,K33-,K63- and K29-linked ubiquitin chains, representing a novel regulatory mechanism (Park et al. xref )."
41204197