IndraLab

Statements

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"Since USP2 stabilizes PGC1α by deubiquitination, USP2 might eliminate mitochondrial ROS by activating the PGC1α–UCP2 axis."
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"In agreement with this, our preliminary experiments showed that the inhibition of USP2 also potentiated mitochondrial ROS production in myotubes."
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"Thus, USP2 seems to prevent ROS production in mitochondria in the muscle cell lineage."
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"Mechanistically, an ML364 treatment experiment suggests that USP2 inhibits the accumulation of ROS in VMH neurons, and thereby leads to continued ATP production in the mitochondria."
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