IndraLab

Statements

AMPK activates KCNB1. 2 / 2
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"In accordance with an AMPK-induced activation of Kv2.1, introduction of active AMPK into cultured hippocampal neurons caused a decrease in the frequency of evoked action potentials."
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"In HEK-293 cells stably expressing KV2.1, AMPK activation using A-769662 caused hyperpolarising shifts in the current–voltage relationship for channel activation and inactivation, which were almost abolished by single (S440A) and completely abolished by double (S440A/S537A) phosphorylation-resistant mutations."
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