IndraLab

Statements

Cholesterol inhibits STING1. 4 / 4
| 4
reach
"However recent work suggests that reduction of cholesterol biosynthesis directly drives the anti-viral response via the ER bound signalling protein STING rather than decreasing nutrient availability to the virus."
28683280
reach
"In turn, high levels of ER cholesterol suppressed the phosphorylation and activation of the ER-resident stimulator of interferon (IFN) gene (STING), leading to reduction of type I interferon (IFN) signaling through antiviral IFNstimulated genes (ISGs) [103] ."
34202098
reach
"Since ER cholesterol enrichment is dependent on de novo cholesterol synthesis, whereas LDLR mediated uptake distributes cholesterol throughout the cell, we hypothesized that DENV depends on de novo cholesterol synthesis to inhibit STING and TBK activation."
32644974
reach
"XREF_BIBR The authors reported that a reduced cholesterol pool size resulting from limited flux through the mevalonate pathway could spontaneously induce a type I IFN response in a stimulator of interferon genes (STING, TMEM173)-dependent fashion."
29123952