IndraLab

Statements

Methylene blue inhibits CASP1. 12 / 12
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"Methylene blue also inhibited recombinant Casp1 and Casp3."
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"Methylene blue attenuates mitochondrial ROS production, phagocytosis, caspase 1 activity, and NLRP3 promoter activity."
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"Furthermore, MSU crystals, another NLRP3 inflammasome trigger, induced caspase-1 and IL-1beta secretion, which were blocked by MB treatment."
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"dsDNA- and Listeria mediated IL-1beta and caspase-1 secretions were significantly blocked by MB co-treatment."
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"MB, together with its derivatives (metabolites), azure A and azure B, is able to stimulate protein degradation and inhibit oxidative damage [XREF_BIBR] and also inhibit the activity of caspase-1 and caspase-3 [XREF_BIBR]."
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"Based on a previous report 17, we speculate that MB inhibits the activity of caspase-1 by oxidizing the catalytic cysteine."
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"As the result, MB dose-dependently attenuated secretion of IL-1beta (p17) and caspase-1 (p20) as well as aggregation of Asc."
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"MB treatment at the 1 st step blocked secretion of IL-1beta, IL-18, and caspase-1, implying that MB interrupts priming of inflammasome activation."
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"MB, together with its derivatives (metabolites), azure A and azure B, is able to stimulate protein degradation and inhibit oxidative damage [184] and also inhibit the activity of caspase-1 and caspase-3 [185]."
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"Furthermore, caspase-1 pathway is downregulated by MB."
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"Furthermore, MB reduced the activity of caspase-1."
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"As the result, MB attenuated caspase-1 and IL-1beta secretion resulting from LPS or E.coli-mediated non canonical inflammasome activation."
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