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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SRC binds EGF and EGFR. 8 / 8
| 8
sparser
"We previously demonstrated that c-Src directly associates with EGFR upon EGF stimulation and c-Src activation contributes to HNSCC cell invasion ( xref )."
sparser
"This mechanism involves the EGF-dependent association of c-Src with HER1 and phosphorylation of the receptor by c-Src on residues Tyr 845 and Tyr 1101."
sparser
"We have previously reported that c-Src directly associates with EGFR in HNSCC cells upon EGF stimulation ( xref )."
sparser
"EGFR and Src interaction with EGF stimulation were also analyzed by the same method ( xref )."
sparser
"Furthermore, it has been reported that Src directly associates with the epidermal growth factor receptor (EGFR) in OSCC cells upon stimulation with EGF and phosphorylates Crk-associated substrate (Cas), podoplanin acting downstream of Src and Cas to promote cell migration."
sparser
"In experimental systems this synergistic growth requires EGF-dependent association of c-Src with the EGFR and phosphorylation of Tyr-845 of the receptor by c-Src."
sparser
"Significantly, both herbimycin A and PP2 abrogated ouabain-induced but not epidermal growth factor-induced Src binding to the EGFR and the subsequent EGFR tyrosine phosphorylation."
sparser
"We have previously demonstrated that c-Src directly associates with EGFR upon EGF stimulation in HNSCC cells ( xref )."