IndraLab

Statements

TIMP1 binds CD44. 9 / 9
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"TIMP1 is associated with inflammatory diseases, acts as a potent cytokine, and binds to several cell-surface receptors [45] including CD63, CD74, CD44, LRP1, and CD82."
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"It is tempting to hypothesize that in agreement with the observations by others MMP-9 or MMP9/TIMP-1 binding to cellular CD44 affects the CD44 signaling [85]."
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"In UT-7 cells, we demonstrated that TIMP-1 binding to a membrane proMMP-9/CD44 complex was a prerequisite for TIMP-1 survival signalling [11] ."
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"CD44 and CD82 are two additional proteins, which have been reported to physically interact with TIMP-1, whereby the interaction of TIMP-1 with CD44 is bridged through proMMP-9 [ xref , xref ]."
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"Previous studies have demonstrated that TIMP-1 binds a proMMP9 and CD44 complex that facilitates erythroid cell survival and is localized to the cell surface [XREF_BIBR]."
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"Our data demonstrate that (i) MMP inhibition is not necessary for TIMP-1-induced erythroid cell survival, (ii) TIMP-1 binds to the cell surface and is not translocated to the nucleus and (iii) TIMP-1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, CD44 also correlates with increased aggressiveness and resistance to radiation therapy and chemotherapeutics (reviewed in xref ) and TIMP-1 binding of the proMMP-9/CD44 complex has been shown to mediate cell survival through Akt activation xref ."
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"When the non-inhibitory TIMP-1/proMMP-9 complex binds receptor CD44, there is an increased survival of red blood cells [63]."
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"Importantly, proMMP-9-binding further confers additional signaling functions to TIMP-1 because, by binding to CD44-anchored proMMP-9, TIMP-1 can initiate antiapoptotic JAK2/PI3K/Akt signaling in eryth[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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