IndraLab

Statements

SMAD2_3 binds USP15. 4 / 4
| 4
sparser
"Finally, we provide evidence that this type of control might operate more widely by showing that interactions between USP15 with SMAD2/3 ( xref ) are subject to USP15 auto-regulation."
26455393
sparser
"Similar to USP4, the interactions between USP15 and its protein target, SMAD2/3 [ xref ], are governed via USP15 self-regulation, while catalytically inactive USP15 lacks the ability to bind to SMAD2/3 protein [ xref ]."
28659380
sparser
"Studies have shown that the substrate SMAD2/3 can interact with WT USP15, and not with a catalytically dead USP15 mutant, implying that there may be an auto-deubiquitination-dependent interaction as well ( xref ; xref )."
34177595
sparser
"In light of our USP4 findings, we tested whether catalytically dead USP15 was still able to interact with one of its established substrates, SMAD2/3 ( xref ), and if this interaction was influenced by C451A mutagenesis."
26455393