IndraLab

Statements

USP7 activates DNA Damage. 8 / 8
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"Importantly, USP7 inhibitor sensitizes cancer cells to chemotherapy by decreasing SAMHD1, suggesting that SAMHD1 stabilization by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity.Tumorigenesis is accompanied by up-regulation of ROS and accumulation of DNA damage, and the former can induce DNA damage and activate the DNA damage repair signaling [34, 35]."
37081042
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"This implies that the stabilization of SAMHD7 by USP7 enhances DNA damage repair to overcome oncogenic stress and influences chemotherapeutic sensitivity [49]."
38787520
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"Interestingly, immunofluorescence analysis targeting endogenous HAUSP and ANXA1 in HeLa cells showed nuclear foci formation of both HAUSP and ANXA1 in the nucleus upon UV induced DNA damage (XREF_FIG), suggesting that HAUSP is possibly involved in the ANXA1 mediated damage response in the nucleus."
25695607
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"USP7 deubiquitinase promotes ubiquitindependent DNA damage signaling by stabilizing RNF168."
29995557
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"USP7 deubiquitinase promotes ubiquitin dependent DNA damage signaling by stabilizing RNF168."
25894431
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"By generating HAUSP knock-down Jurkat cells (HAUSP KD) with a lentiviral shRNA for HAUSP (XREF_FIG), we evaluated the importance of HAUSP in the regulation of ANXA1 upon UV induced DNA damage."
25695607
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"For example, it has been reported that administering USP7 alone or in combination with synergistic pathways significantly enhances DNA damage effects and overcomes treatment resistance (163)."
38322269
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"BRE mediates CDC25A stabilization after DNA damage by USP7."
29416040