
IndraLab
Statements
USP7 activates DNA Damage. 4 / 4
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"Interestingly, immunofluorescence analysis targeting endogenous HAUSP and ANXA1 in HeLa cells showed nuclear foci formation of both HAUSP and ANXA1 in the nucleus upon UV induced DNA damage (XREF_FIG), suggesting that HAUSP is possibly involved in the ANXA1 mediated damage response in the nucleus."
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"By generating HAUSP knock-down Jurkat cells (HAUSP KD) with a lentiviral shRNA for HAUSP (XREF_FIG), we evaluated the importance of HAUSP in the regulation of ANXA1 upon UV induced DNA damage."
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"USP7 deubiquitinase promotes ubiquitin dependent DNA damage signaling by stabilizing RNF168."