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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Benzo[a]pyrene activates USP10. 1 / 1

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"To identify the E3 ubiquitin ligase that mediates BaP induced ACE2 degradation, the expression of several critical E3 ligases, e.g., the F-box (40 amino acid motif)-containing E3 ligase S-phase kinase associated protein 2 (Skp2), beta-transducin repeat containing E3 ubiquitin protein ligase (beta-TRCP), the nuclear interaction partner of ALK (NIPA), the RING finger and WD repeat domain 3 (RFWD3), and deubiquitinase ubiquitin specific protease 10 (USP10) were tested in cells treated with BaP."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...