IndraLab

Statements

Hedgehog activates USP7. 3 / 3
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"Here, we show that Hh stimulated Ci-Cos2 dissociation may also facilitate the binding of Usp7 to Ci, leading to deubiquitination of Ci."
26120032
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"Zhou, et al. showed that Hh stimulates the binding of a ubiquitin-specific protease USP7 to Ci, which positively regulates Hh signaling activity through inhibiting Ci ubiquitination and degradation mediated by both Cul1-Slimb and Cul3-HIB E3 ligases [51]."
| PMC
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"Here, we show that Hh stimulated Usp7 binding to Ci may provide another mechanism to attenuate Hib mediated degradation of Ci A."
26120032