IndraLab

Statements

Hedgehog activates USP7. 3 / 3
| 3
reach
"Here, we show that Hh stimulated Ci-Cos2 dissociation may also facilitate the binding of Usp7 to Ci, leading to deubiquitination of Ci."
26120032
reach
"Here, we show that Hh stimulated Usp7 binding to Ci may provide another mechanism to attenuate Hib mediated degradation of Ci A."
26120032
reach
"Zhou, et al. showed that Hh stimulates the binding of a ubiquitin-specific protease USP7 to Ci, which positively regulates Hh signaling activity through inhibiting Ci ubiquitination and degradation mediated by both Cul1-Slimb and Cul3-HIB E3 ligases [51]."
| PMC