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BK channel inhibitor activates KCNMA1. 3 / 3
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"The rapid effects of 17beta-estradiol on whole cell K + currents were blocked by the BK channel inhibitor paxilline, suggesting a BK channel dependent mechanism."
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"As shown in Fig. 1 B, the application of 1 μM NS11021 increased mean BK channel open probability (Po) from ∼0.21 to 0.38, or 1.81-fold, which was reversed by the BK channel inhibitor paxilline, indica[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As illustrated in Figure XREF_FIG A, the selective BK channel inhibitor paxilline (1mumol/L) completely abolished single BK channel activity (n = 5, N = 5; P < 0.05), suggesting that the stimulatory effect of 17beta-estradiol on channel NPo was due to BK channel activation."
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