IndraLab
Statements
Leu-Val-Ser inhibits CASP1. 1 / 1
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1
reach
"Taken together, these data suggest that F. tularensis LVS expression of mviN was required to limit caspase-1 activation and subsequent cytotoxicity and secretion of IL-1beta and IL-18; and although the mviN mutant was able to replicate within unprimed Mphi in vitro, attenuation of infection by the mviN mutant in vivo was most probably due to increased death of F. tularensis infected Mphi and increased proinflammatory cytokine production."