IndraLab

Statements

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"During follow-up, 58% were treated with methotrexate, 60% were treated with hydroxychloroquine, 32% of patients were treated with other DMARDs and 17% of patients were treated with biologic response modifiers, of which the vast majority (95%) received anti-TNFalpha therapy."
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"With regard to other immunosuppressive treatments prescribed for their RMD, six patients were treated with methotrexate, and one patient was treated with hydroxychloroquine (HCQ)."
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"Instead, it might have been preferable to compare patients treated with methotrexate alone or in combination with hydroxychloroquine to those treated with hydroxychloroquine in order to homogenize the study population and avoid the bias associated with adverse events of the reference treatment."
| PMC
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"(28) Carmichael, S.J., Beal, J., Day, R.O. & Tett, S.E. Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate."
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"[XREF_BIBR] Another study has concluded that hydroxychloroquine increased the potency of methotrexate and also sustained its effect."
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"In contrast, the RA group included significantly more patients treated with methotrexate (p = 0.01) and fewer patients treated with hydroxychloroquine (p = 0.02) compared to the pSS and SLE groups."
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"Monotherapy with hydroxychloroquine is not recommended for patients with RA; however, it is sometimes used in combination with methotrexate, as data suggest hydroxychloroquine might potentiate the effects of methotrexate 6."
| PMC
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"Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose."
21189905