IndraLab

Statements

4-aminopyridine inhibits KCNA5. 5 / 7
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"We first demonstrated that I KCNQ1 was insensitive to concentrations of 4-AP known to inhibit I KCNA5 XREF_BIBR (XREF_FIG)."
20348026
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"However, the sensitivity of sustained outward current to block by relatively low concentrations of 4-AP points to a contribution of Kv1.5 [29] ."
15698836
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"4-AP was shown to inhibit Kv1.1, Kv1.5, Kv2.1, and Kv-3.1 channels at concentrations less that 5 mM [32,33] ."
17118328
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"The reference compound (4-AP) effectively blocked Kv1.5 current with IC 50 ∼400 μM (data not shown)."
18955031
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"Current research indicates that Kv1.5, similar to Kv1.3, is inhibited by 4-AP, TEA, and some new chemicals, such as S0100176 (from Sanofi-Aventis) or diphenyl phosphine oxide-1 (DPO-1) 2."
21423392