IndraLab

Statements

USP19 decreases the amount of MAP1LC3. 3 / 3
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"USP19 knockdown in CSE-treated BEAS-2B cells increased cell survival, OCR, and protein levels of LC3 II/I, reduced TOM20 protein level, and mitigated the reduction in mitochondrial membrane potential."
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"Moreover, the increased protein levels of LC3 II/I and cell survival induced by USP19 knockdown were alleviated by FUNDC1 overexpression in CSE-treated BEAS-2B cells."
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"Western blotting and immunofluorescence experiments of proteins related to autophagy showed that USP19 overexpression substantially reduced the protein expression of P62 in LoVo and SW480 cells while significantly elevating the protein expression of Beclin1 and LC3, as compared to the L-OHP group (Fig. 4B–D)."
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