IndraLab
Statements
sparser
"In further studies, we demonstrated that berberine uniquely downregulated the expression of DAXX in a dose- and time-dependent manner, and because of that DAXX absence in berberine-treated cells, no new formation of the MDM2-DAXX-HAUSP complex was possible, so the p53-induced newly-synthesized MDM2 constitutively underwent self-ubiquitination and degradation."
reach
"In further studies, we demonstrated that berberine uniquely downregulated the expression of DAXX in a dose- and time dependent manner, and because of that DAXX absence in berberine treated cells, no new formation of the MDM2, DAXX, and HAUSP complex was possible, so the p53 induced newly synthesized MDM2 constitutively underwent self ubiquitination and degradation."
reach
"Because berberine induced a similar disruption of the MDM2, DAXX, and HAUSP complex as did doxorubicin, the question raised was why berberine induced a persistent degradation of MDM2, whereas doxorubicin only induced a transient downregulation of MDM2 that was followed by an increase in MDM2 expression."
sparser
"We discovered that downregulation of MDM2 in ALL cells by berberine occurred at a posttranslational level through modulation of death domain-associated protein (DAXX), which disrupted the MDM2-DAXX-HAUSP interactions and thereby promoted MDM2 self-ubiquitination and degradation."