IndraLab

Statements

USP13 binds ACLY. 9 / 9
1 | 8
biogrid
No evidence text available
27892457
sparser
"Mechanistically, Spautin-1 blocks the USP13-ACLY axis, thereby causing mitochondrial damage and releasing DAMPs and cytokines, which promotes the infiltration and activation of CD8 + T cells in DLBCL."
40853486
sparser
"These data indicate that Spautin-1 induces mitochondrial damage by inhibiting the USP13-ACLY axis, thereby suppressing DLBCL growth."
40853486
sparser
"USP13 directly binds to ACLY."
41330897
sparser
"First, the interaction between USP13 and ACLY was confirmed through co-immunoprecipitation analysis."
41330897
sparser
"Mechanistically, Spautin-1 promotes PANoptosis by inducing mitochondrial damage mediated by USP13-ACLY inhibition in DLBCL cells, which in turn induces the release of injury-related molecular patterns and cytokines."
40853486
sparser
"Although our research results indicate that Spautin-1 exerts anti-tumor activity dependent on the induction of PANoptosis, there are still three key limitations that need to be addressed: (1) The mechanism by which Spautin-1 regulates the USP13-ACLY axis has not been thoroughly verified. (2) The expression pattern and prognostic value of USP13 have not yet been verified in clinical samples."
40853486
sparser
"Furthermore, to explore the precise regions responsible for the interaction between USP13 and ACLY, we conducted deletion analyses."
41330897
sparser
"Likewise, we discovered that ACLY’s CoA ligase domain binds to USP13 (Fig. xref )."
41330897